A report of a problem-based learning project on the ethics of terminal care, offered as one of the options available to first year MB ChB students in Edinburgh University Medical School. The project formed part of the 'clinical correlation course' in the new curriculum. Six students took part under the supervision of two clinical tutors and a moral philosopher. The course was case-based and practical with students being given the opportunity over a period of eight weeks to meet patients, relatives (...) and hospital staff at a local geriatrics hospital and terminal care home. The main issue studied was the degree of choice available to patients electing to be treated at home, in hospital or in a hospice. Other issues included: pre-death, disposal of the dead, certification of death, communication with relatives and follow-up bereavement services. (shrink)

Metaseiulus occidentalis is a representative of an important family of mites (Arthropoda: Chelicerata: Acari: Phytoseiidae) that are effective predators of pest mites in agricultural crops around the world. Like many arthropods, this mite contains multiple genomes, including the genomes of several microbial symbionts as well as its own mitochondrial and nuclear genomes. The mitochondrial genome is “mitey” large at 25 kb, due to duplication and triplication of genes. By contrast, the nuclear genome is “mitey” small at 88 Mb. This mite (...) has a parahaploid genetic system, tolerates inbreeding, and has a haploid chromosome number of 3. This predator was genetically improved for use in agriculture by developing strains that lacked the ability to overwinter in diapause or were resistant to multiple pesticides, and can be genetically modified using recombinant DNA methods. Sequencing the nuclear genome would provide useful insights that could enhance genetic improvement programs that would result in improved pest management, could provide genes needed to resolve the evolutionary relationships of this family, and could serve as a model for understanding the evolution and genetics of chelicerate arthropod predators. (shrink)

A number of p rofessionals claim that moral bioenhancement (MB) is n ecessary f or humanity to avert catastrophe. With the rapid advancements of science and technology, human beings have drastically altered their natural and social environments while their moral sensibility continues to be unaffected. They alleged that this is a mismatch, and since it becomes easier to harm than to benefit others, which they anticipate as a global threat, they p romptly want MB to be obligatory to all. But (...) the essay argues that MB is not necessary, and that it is not equivalent to moral enhancement (ME). In keeping with this argument, the essay advances the following: (1) a reexamination of ME and its relation to MB, (2) distinction between bioenhancement and biomedicine (BM), (3) the human being in relation to nature and technology, and (4) the meaning and axiology of MB. (shrink)

Background. The concept of empathy in students has gained significant attention in medical education. Whether implementing formal educational interventions to promote long-term and effective empathy levels leads to sustained increased empathy levels in students, is however less clear. Objectives. The study aimed to evaluate the trajectory of medical students’ self-perceived empathy levels during their 6-year MB ChB degree. Methods. A longitudinal, prospective study was conducted over 4 years. A cohort of 292 medical students was invited to participate. Participants completed the (...) Jefferson Scale of Empathy for Students (JSE-S) at three intervals during their studies. The students attended two workshops related to empathic patient interactions during this time. The JSE-S mean score by age and gender was compared, making use of a linear regression model. Results. A total of 119 students completed the study. Students’ total empathy levels were similar during the first and the last measuring point (110), but there was a significant rise in the intermediate measuring point (113.3). When the male and female cohorts’ scores were interpreted separately, both genders demonstrated a similar pattern to the total score, although females’ JSE-S scores were higher than the males. Conclusion. The results of the study confirm that educational interventions can increase students’ self-perceived empathy levels; however, we suggest that students require reinforcement and multiple opportunities to practise and observe empathic communication with patients to sustain high levels of empathy. Follow-up sessions to specifically target the promotion of empathy should be implemented; otherwise the long-term effect of educational interventions might be limited. (shrink)

To each computable enumerable (c.e.) set A with a particular enumeration {As}s∈ω, there is associated a settling function mA(x), where mA(x) is the last stage when a number less than or equal to x was enumerated into A. One c.e. set A is settling time dominated by another set B (B >st A) if for every computable function f, for all but finitely many x, mB(x) > f(m₄(x)). This settling-time ordering, which is a natural extension to an ordering of the (...) idea of domination, was first introduced by Nabutovsky and Weinberger in [3] and Soare [6]. They desired a sequence of sets descending in this relationship to give results in differential geometry. In this paper we examine properties of the <st ordering. We show that it is not invariant under computable isomorphism, that any countable partial ordering embeds into it, that there are maximal and minimal sets, and that two c.e. sets need not have an inf or sup in the ordering. We also examine a related ordering, the strong settling-time ordering where we require for all computable f and g, for almost all x, mB(x) > f(mA(g(x))). (shrink)

RAID-II is a high-bandwidth, network-attached storage server designed and implemented at the University of California at Berkeley. In this paper, we measure the performance of RAID-II and evaluate various architectural decisions made during the design process. We first measure the end-to-end performance of the system to be approximately 20 MB/s for both disk array reads and writes. We then perform a bottleneck analysis by examining the performance of each individual subsystem and conclude that the disk subsystem limits performance. By adding (...) a custom interconnect board with a high-speed memory and bus system and parity engine, we are able to achieve a performance speedup of 8 to 15 over a comparative system using only off-the-shelf hardware. (shrink)

Some realistic models of neural spiking take into account spike timing, yet the practical relevance of spike timing is often unclear. In Eugene Izhikevich’s model, timing plays a crucial role by al...

The recent MB case involved a dispute between an infant’s parents and his medical team about the appropriateness of continued life support. The dispute reflected uncertainty about two key factors that inform medical decision making for seriously ill infants: both the amount of pain MB experiences and the extent of his cognitive capacities are uncertain. Uncertainty of this order makes decision making in accordance with the best-interests principle very problematic. This article addresses two of the problems that cases such as (...) that of MB pose for those charged with making medical decisions for infants. First, the question of the moral significance of the interest in avoiding pain is considered. It is claimed that this interest can be outweighed by higher-order interests such as those related to autonomy but that where such higher-order interests do not exist, the interest in avoiding pain should be prioritised. Second, the question of how to proceed in cases in which the level of pain or the extent of an infant’s higher-order interests cannot be decisively established is considered. It is suggested that when genuine uncertainty over the interests of an infant exists, parental views about treatment should prevail.The English family courts recently adjudicated on another case involving conflict between parents and a medical team over the provision of life-prolonging medical treatment for an infant. At the time of the ruling, MB was an 18-month-old boy with type I spinal muscular atrophy. His life expectancy was very short , he was almost completely paralysed and he required constant ventilation. MB’s parents wanted a tracheotomy to be performed to facilitate long-term ventilation and allow for some independence from the hospital ward, but the …. (shrink)

Benjamin Pradel est sociologue spécialisé dans les mobilités durables et les études urbaines. Il est consultant-chercheur à Kaleido'Scop – [email protected]. Résumé : Le concept de mobilité embrasse à la fois la grande échelle des mouvements des personnes, objets, capitaux et informations à travers le monde et les processus plus locaux des déplacements quotidiens, des mouvements dans les espaces publics et du transport des objets au jour le jour. La mobilité - Sociologie.

David DeGrazia1 offers, to my mind, a decisive response to the bioconservative suggestion that moral bioenhancement threatens human freedom or undermines its value. In this brief commentary, I take issue with DeGrazia's way of defining MB. A different concept of MB exposes a danger missed by his analysis.Two ways to define MBDeGrazia presents MB as a form of enhancement directed at moral capacities. There are, in the philosophical literature, two broad approaches to defining human enhancement. Simplifying somewhat, one account identifies (...) enhancement with improvement. DeGrazia joins other advocates of MB in preferring this type of account, defining a human enhancement as ‘any deliberate intervention that aims to improve an existing capacity, select for a desired capacity, or create a new capacity in a human being.’1An alternative approach relativises enhancement to human norms.2 ,3 In this view, improvements up to levels of functioning properly considered normal for humans are therapy, not enhancement. Improvements beyond those levels are enhancements. The injection of synthetic erythropoietin by someone suffering from anaemia is therapy. When healthy Tour de France competitors inject EPO, it is enhancement.We can minimise philosophical disputes about word meanings by endorsing a conceptual pluralism that acknowledges the need for more than one concept of human enhancement to address the hugely varied ways in which technology may alter humans. In the debate about biomedical moral improvements there would be enhancement as improvement and enhancement beyond human norms.DeGrazia effectively deploys the concept of enhancement as improvement to …. (shrink)

The book presents the most relevant theories of truth (correspondence, semantic, deflational, pragmaticist, coherentist, constructivist, evidential), with the emphasis of analytical approaches. The author develops a version of the realist correspondence concept of truth while distinguishing various criteria of truth. He is skeptical in regard of any, complete or certain truth but he does not accept epistemic skepticism either, but argues for a moderate realism where objective orientation towards truth suffices as catching (ever) more truth than falsity.